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Cat. No.: PLMS-0.2 (for 10mM×0.2ml)

Cat. No.: PLMS-5 (for 5mg)

Cat. No.: PLMS-25 (for 25mg)

Cat. No.: PLMS-100 (for 100mg)

Description

Poliumoside, a caffeoylated phenylpropanoid glycoside, is extracted from the stems and leaves of Brandisia hancei. It exhibits notable properties as an inhibitor of advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR), with IC50 values of 19.69 μM and 8.47 μM, respectively. Additionally, Poliumoside showcases anti-inflammatory and antioxidant effects.

Basic Information

• Aliases: -
• Source: Callicarpa bodinieri Levl.; Callicarpa kwangtungensis Chun
• Compound type: Phenylpropanoids > Phenylpropanoic acids
• Chemical Formula: C₃₅H₄₆O₁₉
• Molecular Weight: 770.73
• CAS Number: 94079-81-9
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/ml (129.75 mM); Ethanol: 50 mg/ml (64.87 mM)
• Solution Preparation: Add 10mg to 1.30ml of DMSO, or add 7.71mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

-

In Vitro Study

Poliumoside effectively inhibits AGE formation and RLAR, boasting IC50 values of 19.69 μM and 8.47 μM, respectively. Furthermore, in vitro studies demonstrate its capability to inhibit AAPH-induced hemolysis of rat red blood cells within a concentration range of 5-30 μM over a 3-hour period. Moreover, when pre-treated for 2 hours with concentrations ranging from 12.5 to 100 μM, Poliumoside effectively suppresses the release of TNF-α and IL-6 in LPS-induced RAW 264.7 cells.

In Vivo Study

Poliumoside suppresses vessel dilation in larval zebrafish.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory