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Cat. No.: OSTL-0.2 (for 10mM×0.2ml)

Cat. No.: OSTL-25 (for 25mg)

Cat. No.: OSTL-100 (for 100mg)

Description

Osthole (Osthol) serves as a natural alternative to antihistamines. It exhibits potential as an inhibitor of histamine H1 receptor activity and also suppresses HBV secretion in cells.

Basic Information

• Aliases: Osthenol methylether
• Source: Angelica pubescens Maxim. f. biserrata Shan et Yuan
• Compound type: Phenylpropanoids > Coumarins > Angular Furano-Coumarins
• Chemical Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• CAS Number: 484-12-8
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 100 mg/ml (409.35 mM)
• Solution Preparation: Add 3mg to 1.23ml of DMSO, or alternatively, add 2.44mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

-

In Vitro Study

Osthole (p<0.0001) and Fexofenadine (p<0.001) effectively inhibit the increased expression of HRH-1 mRNA induced by histamine in the study group. This inhibitory effect is also evident in cells cultured with histamine/Osthole, where the combination significantly reduces HRH-1 mRNA expression compared to histamine alone (p<0.0001). Assessment of cell viability reveals no obvious toxicity at Osthole doses up to 100 µM; however, toxicity becomes apparent at doses of 500 µM. Therefore, Osthole is utilized in all in vitro studies within the dose range of 10 to 100 µM. Osthole dose-dependently promotes osteoblast differentiation, as evidenced by the upregulation of osteoblast differentiation marker genes such as type I collagen (col1), bone sialoprotein (BSP), and osteocalcin (OC) after 2 days of culture. Additionally, Osthole enhances ALP activity in mouse primary osteoblasts in a dose-dependent manner.

In Vivo Study

N/A

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory