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Cat. No.: NBPAG-100 (for 100μg)

Description

N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of heart failure. When cardiomyocytes are stimulated by pressure or stretch—such as when ventricular volume expands and pressure load increases—a 134-amino acid precursor B-type natriuretic peptide (pre-proBNP) is first formed. Then, protease cleaves the N-terminal 26-amino acid signal peptide, converting it into pro-B-type natriuretic peptide (proBNP) containing 108 amino acids. This proBNP is further cleaved by endonuclease into an N-terminal NT-proBNP containing 76 amino acids and a cyclic structure containing a 32-amino acid BNP. Both polypeptides are released into the bloodstream.

The biological half-life of NT-proBNP is 60-120 minutes, whereas the biological half-life of BNP is 18 minutes. Detecting NT-proBNP is more stable and accurate.

Protein Type

Recombinant, with his tag

Molecular Weight

12kDa

Source

E.coli

Form

Liquid 

Buffer

0.01M PBS, pH 7.4, 15% Glycerol, 0.1% Proclin300 

Purification Method

Affinity purified 

Purity

≥ 90% by SDS-PAGE 

Storage

Shipped at 2-8 ℃. Upon delivery, aliquot and store at -20±5℃. Avoid freeze/thaw cycles. 

Application

Calibrator or standard in immunoassays.

Matters Needing Attention

This product contains a preservative. Standard Laboratory Practices should be followed when handling this material.

Note

Centrifuge before opening to ensure vial contents are completely collected.

Only for research and not intended for treatment of humans or animals

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