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Cat. No.: NBPT6-500 (for NT-ProBNP Antibody-T6, 500μg)

Cat. No.: NBPT9-500 (for NT-ProBNP Antibody-T9, 500μg)

Cat. No.: NBPC7-500 (for NT-ProBNP Antibody-6C7, 500μg)

NT-ProBNP Antibody-T6 

• Clone: T6
• Source: CHO
• Isotype: Goat IgG1 

NT-ProBNP Antibody-T9

• Clone: T9
• Source: CHO
• Isotype: Rabbit IgG1 

NT-ProBNP Antibody-6C7 

• Clone: 6C7
• Source: Mouse ascites
• Isotype: Mouse IgG1 

Description

N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of heart failure. When cardiomyocytes are stimulated by pressure or stretch—such as when ventricular volume expands and pressure load increases—a 134-amino acid precursor B-type natriuretic peptide (pre-proBNP) is first formed. Protease then cleaves the N-terminal 26-amino acid signal peptide, converting it into pro-B-type natriuretic peptide (proBNP) containing 108 amino acids. This proBNP is further cleaved by endonuclease into an N-terminal NT-proBNP containing 76 amino acids and a cyclic structure containing a 32-amino acid BNP. Both polypeptides are released into the bloodstream.

The biological half-life of NT-proBNP is 60-120 minutes, whereas the biological half-life of BNP is 18 minutes. Detecting NT-proBNP is more stable and accurate.

Specificity

Human N-terminal Prohormone of Brain Natriuretic Peptide 

Form

Liquid

Buffer:

• T6: 0.01M PBS, pH 7.4, 0.1% Proclin300

• T9: 0.01M PBS, pH 7.4, 0.2% Proclin300

• 6C7: 0.01M PBS, pH 7.4, 0.2% Proclin300

Purification Method

Affinity purified 

Purity

≥95% by SDS-PAGE

Storage

Shipped at 2-8 ℃. Upon delivery, aliquot and store at -20±5℃. Avoid freeze/thaw cycles.

Application Platform

ELISA, CLIA, LFIA

Matters Needing Attention

This product contains a preservative. Standard Laboratory Practices should be followed when handling this material.

Note

Centrifuge before opening to ensure vial contents are completely collected.

Only for research and not intended for treatment of humans or animals

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