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Cat. No.: NRGN-0.2 (for 10mM×0.2ml)

Cat. No.: NRGN-25 (for 25mg)

Cat. No.: NRGN-100 (for 100mg)

Description

Naringin, a prominent flavanone glycoside found in tomatoes, grapefruits, and various citrus fruits, showcases diverse biological properties, including antioxidative, anti-inflammatory, and antiapoptotic activities.

Basic Information

• Aliases: Naringenin 7-Rhamnoglucoside; Naringoside; Aurantin; Isohesperidin
• Source: Citrus medica L.; Citrus aurantium L.; Citrus sinensis Osbeck
• Compound type: Flavonoids > Flavones > Dihydroflavones
• Chemical Formula: C₂₇H₃₂O₁₄
• Molecular Weight: 580.53
• CAS Number: 10236-47-2
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 91 mg/ml (156.8 mM); Ethanol: 1 mg/ml (1.7 mM); Water: <1 mg/ml
• Solution Preparation: 10mg added to 1.72ml DMSO, or 5.81mg added to 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

NF-κB

In Vitro Study

Naringin suppresses the activation of the NF-κB signaling pathway. Naringenin inhibits high glucose-induced proliferation, inflammatory reactions, and oxidative stress injury in HBZY-1 cells. Naringin inhibits the proliferation of AGS cancer cells in a dose- and time-dependent manner. Phosphorylation of PI3K and its downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells and activates autophagy-related proteins. Naringin protects PC12 cells from 3-NP neurotoxicity by decreasing lactate dehydrogenase release in 3-NP-induced PC12 cells and enhancing antioxidant defense through increased enzymatic antioxidant activities and reduced glutathione levels.

In Vivo Study

Treatment with naringin significantly alleviates renal injury in diabetic rats and significantly increases the body weight of diabetic rats. Administration of naringin effectively reduces collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin results in decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), along with increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Oral administration of naringin significantly improves learning and memory abilities. Naringin also significantly enhances the insulin signaling pathway.

Clinical Trial

NCT01423019: Weight Loss, Not Applicable.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory