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Cat. No.: HTRKBH-25 (for 25μg)

Cat. No.: HTRKBH-50 (for 50μg)

Cat. No.: HTRKBH-100 (for 100μg)

Description

Tropomyosin receptor kinase B (TrkB) serves as the high-affinity catalytic receptor for several neurotrophins, which are small protein growth factors pivotal in inducing the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB include Brain Derived Neurotrophic Factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3).

Initially identified as an oncogenic fusion in 1982, the Trk family has recently regained attention due to its implications in human cancers. This resurgence stems from the discovery of gene fusions and other oncogenic alterations involving NTRK1 (TrkA), NTRK2 (TrkB), and NTRK3 (TrkC) in various tumor types. Clinical trials investigating Trk inhibitors have shown promising preliminary results, indicating their potential in shrinking human tumors.

Beyond oncology, TrkB and its ligand BDNF have been linked to both normal brain function and the pathophysiology of Alzheimer’s disease (AD) and other neurodegenerative disorders. This association underscores the diverse roles of TrkB signaling in neurological health and disease progression.

Species

Human

Molecular Alias

GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2

Accession

Q16620

Expression Sequence

Protein sequence(Q16620, Trp230-His430, with C-10*His)

WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 24kDa 

Actual: 35-45kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt when stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.