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Cat. No.: HTAUH-50 (for 50μg)

Cat. No.: HTAUH-100 (for 100μg)

Cat. No.: HTAUH-500 (for 500μg)

Cat. No.: HTAUH-1k (for 1mg)

Description

Tau proteins (abbreviated from tubulin associated unit) are a group of six highly soluble protein isoforms produced by alternative splicing of the MAPT gene (microtubule-associated protein tau). These proteins primarily help maintain the stability of microtubules in axons and are abundant in the neurons of the central nervous system (CNS), with the cerebral cortex having the highest concentration. Hyperphosphorylation of tau proteins (tau inclusions, pTau) can lead to the self-assembly of tangles of paired helical filaments and straight filaments, which are implicated in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Species

Human

Molecular Alias

Neurofibrillary tangle protein, Paired helical filament-tau (PHF-tau)

Accession

P10636-2

Expression Sequence

Protein sequence(P10636-2, Met1-Gln186 with C-10*His)

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQGGGGSHHHHHHHHHH

Expression Host

E.coli

Molecular Weight

Theoretical: 20.9kDa 

Actual: 29kDa

Purity

95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.