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Cat. No.: HPAPPAH-50 (for 50μg)

Cat. No.: HPAPPAH-100 (for 100μg)

Description

Pappalysin-1, also known as pregnancy-associated plasma protein A (PAPPA), is a protein encoded by the PAPPA gene in humans. This secreted protease primarily targets insulin-like growth factor binding proteins. Pappalysin-1 is also employed in screening tests for Down syndrome. Its proteolytic function is activated upon binding to collagen, and it is believed to play a role in local proliferative processes such as wound healing and bone remodeling. Additionally, low plasma levels of PAPPA have been suggested as a biochemical marker for pregnancies involving aneuploid fetuses (fetuses with an abnormal number of chromosomes).

Species

Human

Molecular Alias

Pappalysin-1, Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGF-dependent IGFBP-4 protease; IGFBP-4ase)

Accession

Q13219

Expression Sequence

Protein sequence (Q13219, Pro1200-Gly1627, with C-10*His):

PAEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKDLRGYSHGGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 48.8 kDa

Actual: 65 kDa

Purity

95% by SDS-PAGE

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.