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Cat. No.: HIGF1H-50 (for 50μg)

Cat. No.: HIGF1H-100 (for 100μg)

Cat. No.: HIGF1H-500 (for 500μg)

Description

Insulin-like growth factor-binding protein 1 (IGFBP-1), also known as placental protein 12 (PP12), is a protein encoded by the IGFBP1 gene in humans. This protein binds to both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Its binding prolongs the half-life of the IGFs and modifies their interaction with cell surface receptors. Various alternate transcriptional splice variants, encoding different isoforms, have been identified.

Serum IGFBP-1 demonstrates high diagnostic accuracy for early-stage esophageal squamous cell carcinoma (ESCC), esophagogastric junction adenocarcinoma (EJA), stomach, and other cancers.

Species

Human

Molecular Alias

IBP-1, IGF-binding protein 1,Placental protein 12 (PP12)

Accession

P08833

Expression Sequence

Protein sequence(P08833, Ala26-Asn259 with C-10*His)

APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQNGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 26.9kDa 

Actual: 30kDa

Purity

95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.