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Cat. No.: HGZMBH-25 (for 25μg)

Cat. No.: HGZMBH-50 (for 50μg)

Cat. No.: HGZMBH-100 (for 100μg)

Description

Granzyme B (GZMB) stands as a prominent serine protease primarily localized within the granules of natural killer (NK) cells and cytotoxic T cells. This enzyme, alongside the pore-forming protein perforin, is deployed by these immune cells to orchestrate apoptosis in target cells. Interestingly, granzyme B isn't confined solely to cytotoxic cells; it's also synthesized by a diverse array of non-cytotoxic cells spanning from basophils and mast cells to smooth muscle cells.

Beyond its primary role in inducing apoptosis, granzyme B boasts a myriad of secondary functions. It has been implicated in instigating inflammation by eliciting cytokine release and partaking in extracellular matrix remodeling, thereby underlining its multifaceted involvement in immune regulation and tissue homeostasis.

Species

Human

Molecular Alias

C11, CTLA-1, Cathepsin G-like 1 (CTSGL1), Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease), Fragmentin-2, Granzyme-2, Human lymphocyte protein (HLP), SECT, T-cell serine protease 1-3E, CGL1, CSPB, GRB

Accession

P10144

Expression Sequence

Protein sequence(P10144, Gly19-Tyr247, with C-10*His)

GEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRYGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 27.4kDa 

Actual: 33kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt when stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.