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Cat. No.: HC3L1H-25 (for 25μg)

Cat. No.: HC3L1H-50 (for 50μg)

Cat. No.: HC3L1H-100 (for 100μg)

Description

Non-enzymatic chitinase-3-like protein 1 (CHI3L1) belongs to glycoside hydrolase family 18. CHI3L1 is synthesized and secreted by a variety of cells, including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle cells, and tumor cells. It plays a significant role in tissue injury, inflammation, tissue repair, and remodeling responses. CHI3L1 has been strongly associated with several diseases, including asthma, arthritis, sepsis, diabetes, liver fibrosis, and coronary artery disease. Additionally, CHI3L1 is overexpressed in numerous human cancers and animal tumor models. CHI3L1 signaling is crucial for cancer cell growth, proliferation, invasion, metastasis, angiogenesis, activation of tumor-associated macrophages, and Th2 polarization of CD4+ T cells.

Species

Human

Molecular Alias

39 kDa synovial protein, Cartilage glycoprotein 39 (CGP-39; GP-39; hCGP-39), YKL-40

Accession

P36222

Expression Sequence

Protein sequence(P36222, Tyr22-Thr383, with C-10*His)

YKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAATGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 42.1kDa 

Actual: 42kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.