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Cat. No.: MKEXU-10 (for 10mg)

Cat. No.: MKEXU-100 (for 10mg×10)

Cat. No.: MKEXU-1k (for 10mg×100)

Description

Exosomes from Milk (Ultrapure) are high-purity exosomes derived from premium-grade cow milk, with a purity of ≥98%. They can be used for drug loading and targeted delivery, as well as a positive control for exosome isolation and function research. These exosomes are widely applied in the fields of biology and medicine.

Exosomes are membrane-bound extracellular vesicles (EVs) with a diameter of approximately 40-160 nm and a lipid bilayer structure. They naturally occur in blood, urine, cerebrospinal fluid, and the supernatant of cultured cells. Almost all cell types can produce and release exosomes. The cell membrane undergoes endocytosis to form early sorting endosomes (ESE), late sorting endosomes (LSE), and multivesicular bodies (MVB), which contain intraluminal vesicles (ILVs). MVBs fuse with the cell membrane to form exosomes. These exosomes carry various components from their parent cells, including nucleic acids, proteins, lipids, carbohydrates, and metabolites, and release them into the extracellular matrix. Exosomes can be recognized and fused by nearby or distant cells, acting as important mediators of intercellular regulation. They play a role in the pathogenesis of various diseases, including cancer, neurodegenerative diseases, and inflammatory diseases, affecting many cellular functions.

Milk exosomes contain a rich variety of exosomes from multiple cell sources. Milk exosomes, also known as Milk Exosomes (ME), have a phospholipid bilayer membrane structure similar to cell membranes, tightly encapsulating specific proteins such as cytokines, growth factors, lipids, miRNA, DNA fragments, etc. Research has shown that milk exosomes can maintain the integrity of their contents under the highly acidic conditions of the stomach and the degradative conditions of the intestine. They possess the ability to rapidly cross biological barriers and target specific tissues. The excellent biocompatibility, low immunogenicity, and high stability of milk exosomes make them not only important carriers for drug loading and targeted delivery but also valuable tools in exosome-related research.

Features

• This product offers good consistency and reproducibility. By using Nanoparticles Tracking Analysis (NTA) to quantify and validate the protein content and particle number of exosomes, this product ensures high stability, thereby guaranteeing the reliability and reproducibility of experimental results.
• This product is high in content and purity. Each 10 mg contains approximately 3×10¹² exosome particles, separated and purified using a non-ultracentrifugation process. This method avoids potential damage to exosomes caused by ultracentrifugation and ensures a purity of over 98%, effectively preventing interference from other substances in milk during experiments.
• This product is convenient to use. It is stored in lyophilized (freeze-dried) form, with the buffer before lyophilization being PBS (pH 7.4) containing small amounts of lyoprotectants like sucrose and mannitol, which do not alter the stability of exosome proteins and nucleic acids. Packaged in vials, it can be used after dissolving in pure water, typically adding 2 ml of pure water per 10 mg of product. Once dissolved, it forms a slightly milky, transparent solution.

Storage

Store at 4ºC, valid for one year.

Precautions

• After dissolving, aliquot appropriately and store at -80ºC, valid for six months. Once taken out, use it up as much as possible to avoid repeated freeze-thaw cycles.
• Avoid excessive mixing or shaking to prevent exosome aggregation.
• This product is intended for scientific research use only by professionals and must not be used for clinical diagnosis or treatment, food or drugs, or stored in a regular household.
• For your safety and health, wear a lab coat and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory