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Cat. No.: EGNL-25 (for 25mg)

Cat. No.: EGNL-100 (for 100mg)

Description

Eugenol, an essential oil derived from cloves, exhibits antibacterial, anthelmintic, and antioxidant properties. It has been demonstrated to effectively inhibit lipid peroxidation.

Basic Information

• Aliases: 4-Allyl-2-methoxyphenol; 5-Allylguaiacol
• Source: Eugenia caryophyllata Thunb.; Myristica fragrans Houtt.
• Compound type: Phenylpropanoids > Phenylpropanes
• Chemical Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.21
• CAS Number: 97-53-0
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 100 mg/ml (609.01 mM)
• Solution Preparation: Add 2mg to 1.22ml of DMSO, or add 1.64mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

In Vitro Study

The essential oil of O. gratissimum, along with eugenol, demonstrates efficacy in inhibiting the hatching of H. contortus eggs, suggesting potential applications in the treatment of gastrointestinal helminth infections in small ruminants. Both the essential oil and eugenol exhibit maximum inhibition of egg hatching at a concentration of 0.50%. Eugenol inhibits the generation of superoxide anions in the xanthine-xanthine oxidase system by 50% at concentrations of 250 μM and also inhibits the production of hydroxyl radicals by 70%. Furthermore, eugenol inhibits hydroxyl radical formation, as measured by the hydroxylation of salicylate to 2,3-dihydroxybenzoate, by 46% at 250 μM.

Eugenol protects against stress-induced development of irritable bowel syndrome (IBS)-like gastrointestinal dysfunction through modulation of the hypothalamic-pituitary-adrenal (HPA) axis and brain monoaminergic pathways, in addition to its antioxidant properties. Administration of eugenol at 50 mg/kg reduces 80% of stress-induced increase in fecal pellets, comparable to the effect of ondansetron. Moreover, eugenol attenuates 80% of stress-induced elevation in plasma corticosterone levels and modulates the serotonergic system in the prefrontal cortex (PFC) and amygdala. It also mitigates stress-induced alterations in norepinephrine levels and enhances the antioxidant defense system in all brain regions.

In Vivo Study

Eugenol (33 mg/kg) administered orally for 2 days causes significant suppression of knee joint edema, which continues to be significantly reduced at the end of the treatment. After 2 days, eugenol-treated mycobacterial arthritic rats show a marked reduction in paw swelling.

Clinical Trial

NCT03437655: MTA|Dental Restoration, Temporary, Not Applicable.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory