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Cat. No.: DAB-5 (for 5mg)

Cat. No.: DAB-25 (for 25mg)

Alternative Names 

Dabcyl/Edans-CoV Main Protease (Mpro) Substrate; Dabcyl/Edans Mpro Substrate; Dabcyl/Edans 3CLpro Substrate; CoV 3CL Protease Fluorogenic Substrate (Dabcyl/Edans); CoV Main Protease Fluorescent Substrate (Dabcyl/Edans); CoV 3CL Protease Fluorescent Substrate (Dabcyl/Edans)

Description 

Dabcyl-KTSAVLQSGFRKME-Edans is a substrate for coronavirus Mpro/3CLpro, based on fluorescence resonance energy transfer (FRET). After cleavage, this substrate releases the fluorescent group Edans, with a maximum excitation wavelength of 340 nm and maximum emission wavelength of 490 nm. By measuring fluorescence, Mpro activity can be detected. Since the COVID-19 pandemic at the end of 2019, this substrate has been widely used in screening kits for Mpro/3CLpro inhibitors or in detecting kits for Mpro/3CLpro protease activity of the novel coronavirus (2019-nCoV).

Purity 

>98%

Molecular Weight 

2081.44

Sequence 

Dabcyl-KTSAVLQSGFRKME-Edans

Source 

Synthetic

Formulation

5 mg dissolved in 120 µl DMSO, or 41.62 mg dissolved in 1 ml DMSO to prepare a 20 mM solution. This product is provided in a 20 mM concentration using DMSO.

Storage Conditions

Store in a dark place at -20℃. The product is valid for one year.

Precautions

• If using small amounts or using frequently, consider aliquoting and storing at -20℃ in the dark. Repeated freeze-thaw cycles can affect the product's performance.
• This product is intended for scientific research use by professionals only and must not be used for clinical diagnostics or treatments, food or drug applications, and must not be stored in a regular household.
• For your safety and health, please wear a lab coat and disposable gloves while handling.

Related:

• MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 (Coronavirus Main Protease Fluorogenic Substrate)
• Dabcyl-KTSAVLQSGFRKME-Edans (Coronavirus Main Protease Fluorogenic Substrate)
• MCA-YVADAPK(Dnp)-OH (ACE2 Fluorogenic Substrate)
• MCA-APK(Dnp)-OH (ACE2 Fluorogenic Substrate)
• MCA-EIDLMVLDK-Dnp (BACE1 Fluorogenic Substrate)

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Only for research and not intended for treatment of humans or animals

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