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Cat. No.: ADL

Description

Approved Drug Library, also known as the Approved Drug Compound Library, FDA Approved Drug Library, or FDA Approved Drug Compound Library, includes a total of 2818 active pharmaceutical ingredient compounds of drugs approved by official drug regulatory agencies such as the FDA, EMA, and NMPA. This library is particularly suitable for initial priority screening in drug discovery systems. If researchers have established a drug screening system and wish to screen for effective drugs, the Approved Drug Library is the most recommended compound library to consider.

These compounds have undergone extensive and rigorous preclinical and clinical studies, with validated biological activity and safety. Their activity is well-defined and targets are known, making them suitable for high-throughput screening (HTS) and high-content screening (HCS). This library serves as an excellent tool for drug repurposing, aiding in the identification of new targets for existing drugs and significantly accelerating the drug development process.

Traditional new drug development involves steps such as target validation, compound screening, candidate compound determination, preclinical research, and clinical research. This is a time-consuming and costly process. With the decreasing availability of good drug targets and the increasing requirements for drug safety and efficacy in clinical studies, the cost of new drug development has been continuously rising, far exceeding the level of ten years and ten billion dollars.

In recent years, drug repurposing or new uses for old drugs have gained increasing attention from drug developers and researchers. With the advancement of high-throughput and high-content screening platforms, the discovery of new biomarkers, and the rapid development of bioinformatics, approved drugs, with their validated biological activity, pharmacokinetic properties, safety, and bioavailability, can significantly accelerate target-based or cell-based drug development and optimization, reduce drug development costs and failure risks, and shorten development cycles.

Due to the defined activity and known targets of compounds in the Approved Drug Library, many researchers screen drugs from this library for new indications, new biological functions, or pharmacological regulation of physiological and pathological processes. They also use specific drug combinations for screening small molecules that induce cell differentiation. By combining one or a few small molecules, they select compounds that induce various somatic cells into induced pluripotent stem cells, neural precursor cells, myocardial cells, etc. There have even been successful attempts to achieve induced differentiation in vivo using small molecule combinations.

This Approved Drug Library contains 2818 active pharmaceutical ingredient compounds of drugs approved by authoritative drug regulatory agencies such as the FDA (Food and Drug Administration), EMA (European Medicines Agency), or NMPA (National Medical Products Administration). All compounds are prepared in DMSO, with each set comprising 36 V-bottom 96-well plates, sealed with aluminum foil plate seals. Each plate is labeled with barcode information for easy identification of the corresponding compounds.

Features

• Approved Drug Library provides complete compound information, including compound English names, CAS numbers, molecular weights, targets and signaling pathways, compound structures, IC50 values, and activity descriptions. Below is the download link for the detailed list of this library: Approved Drug Library List.
• High Quality of Compounds in the Approved Drug Library: All compounds have been validated through clinical trials, confirming their biological activity and safety. The compounds exhibit diverse structures and significant efficacy, are cell-permeable, and have been verified for correct structure and high purity by NMR and HPLC/LCMS analyses.
• Broad Coverage of Research Fields: The compounds in the Approved Drug Library span various research fields, including oncology, cardiovascular drugs, anti-inflammatory responses, immunity/immune system drugs, nervous system drugs, respiratory drugs, dermatology, endocrinology, and more.
• Involvement in Multiple Signaling Pathways: The compounds in the Approved Drug Library are associated with multiple signaling pathways, such as Anti-infection, Apoptosis, Autophagy, DNA Damage/DNA Repair, GPCR, NF-κB, PI3K/Akt/mTOR, JAK/STAT, Tyrosine Kinase/Adaptors, TGF-β/Smad, MAPK/ERK, Metabolism, Proteases/Proteasome, Immunology/Inflammation, Microbiology/Virology, Neuroscience, Stem Cells, Membrane Transporter/Ion Channel, and more.
• Convenient and Flexible Use: The Approved Drug Library is stored in V-bottom 96-well plates, suitable for both automated equipment and manual pipetting or individual validation. The V-bottom design minimizes dead volume. The first and twelfth columns of each 96-well plate are left blank for adding DMSO or other controls, also helping to reduce edge effects during cell culture. For manual drug screening, the product includes 36 drug plates. Assuming each person screens 2-4 plates per day, one person can complete a round of screening in 9-18 working days.
• High Cost-Effectiveness for Large-Scale Screening: The compounds in the Approved Drug Library are prepared at a standard concentration of 10mM, with a volume of 10µl. When processing cells at a final concentration of 10µM, each 200µl well in a 96-well plate can be used for approximately 50 screenings; each 50µl well in a 384-well plate can be used for approximately 200 screenings.

Storage

• Store at -20ºC, effective for at least one year.
• Store at -80ºC, effective for at least two years.

Precautions

• Place the 96-well plates in a well-sealed container along with some desiccant, and then freeze them at the appropriate temperature. After each thawing, ensure the exterior of the plates remains dry by using absorbent paper to wipe off any moisture on the surface of the 96-well plates.
• Before removing the aluminum foil plate seal, make sure the 96-well plates return to room temperature and are properly centrifuged (5000 rpm, 30 seconds) to prevent any liquid from adhering to the plate walls or the aluminum foil seal.
• The compounds in the Approved Drug Library are clinical-grade active pharmaceutical ingredients with relatively good stability and long shelf life. However, it is still recommended to store them at low temperatures.
• When resealing the plates, use low-temperature resistant plate seals and keep the plates upright, avoiding sideways or upside-down positions.
• This product is intended solely for scientific research by professionals and is not to be used for clinical diagnostics or treatments, food or drug purposes, or stored in ordinary residences.
• For your safety and health, please wear a lab coat and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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