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Cat. No.: AMTF-0.2 (for 10mM×0.2ml)

Cat. No.: AMTF-5 (for 5mg)

Cat. No.: AMTF-25 (for 25mg)

Cat. No.: AMTF-100 (for 100mg)

Description

Amentoflavone is a natural biflavone compound renowned for its diverse biological properties, encompassing anti-inflammatory, antioxidative, and neuroprotective effects.

Basic Information

• Aliases: Didemethyl-ginkgetin
• Source: Selaginella tamariscina (Beauv.) Spring; Selaginella pulvinata (Hook. et Grev.) Maxim.
• Compound type: Flavonoids > Flavones
• Chemical Formula: C₃₀H₁₈O₁₀
• Molecular Weight: 538.46
• CAS Number: 1617-53-4
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 34 mg/ml (63.14 mM)
• Solution Preparation: Add 10mg to 1.86ml DMSO, or 5.38mg to 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

Apoptosis

In Vitro Study

In irradiated V79 cells, pretreatment with amentoflavone 24 hours before exposure to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, and decreased the concentration of reactive oxygen species (ROS) and mitochondrial mass. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concentration of amentoflavone (150 μmol/L) clearly induced apoptosis in the cells.

In Vivo Study

In epilepsy models, amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model. It suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons, resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory