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Cat. No.: 2DG-98-1 (for >98% purity, 1g)

Cat. No.: 2DG-98-5 (for >98% purity, 5g)

Cat. No.: 2DG-99-1 (for >99% purity, 1g)

Cat. No.: 2DG-99-5 (for >99% purity, 5g)

Description

2-Deoxy-D-glucose (2-DG) is used in glucose receptor research to induce and study counter-regulatory responses (CRR). It is also used in developing anti-cancer strategies involving radiosensitization, chemosensitization, and oxidative stress.

CAS Number: 154-17-6
Chemical Formula: C₆H₁₂O₅
Molecular Weight: 164.16

General Information:

• Name (English): 2-Deoxy-D-glucose
• Specifications: Reagent grade, ≥99% (GC), crystalline
• Synonym (English): 2-Deoxyglucose; 2-Deoxy-D-arabinohexose
• Beilstein Registry No: 1723331
• EINECS Number: 205-823-0
• MDL Number: MFCD00151328
• UNSPSC Code: 12352201

Biochemical/Physiological Actions

2-Deoxy-D-glucose (2-DG) is a glucose analog that inhibits glycolysis by acting on hexokinase (the rate-limiting step of glycolysis). It is phosphorylated by hexokinase to 2-DG-P, which cannot be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in cells and depletion of cellular ATP. In vitro, 2-DG induces autophagy, increases ROS production, and activates AMPK.

Storage

Store at room temperature.

Precautions

• This product is intended for scientific research use only by professionals. It is not to be used for clinical diagnosis or treatment, nor for food or drug purposes, and should not be stored in residential areas. 
• For your safety and health, please wear a lab coat and disposable gloves when handling this product.

Only for research and not intended for treatment of humans or animals

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