Increased Thermal Stability of qPCR Probes

• Improved affinity and specificity
• Reduced background fluorescence
• Better signal-to-noise ratio

Enhanced Single Nucleotide Discrimination

• Greatly enhanced discrimination between alleles via single nucleotide polymorphism (SNP)
• Better mismatch discrimination compared to native-state DNA probes

Multiplex qPCR Systems

• Normalization of the Tm across several short sequences with varying GC-content gets accessible
• Optimal design of highly-specific, shorter probes
• Particularly beneficial for microarray and multiplex PCR applications

Antisense Technology

• Enhanced binding affinity to complementary nucleic acids
• High nuclease resistance
• Further increase in nuclease resistance by the introduction of a phosphorothioate backbone

* The price of custom LNA oligo is dependent on the length, yield, and number. Please indicate the specifics in the quote request.

Featured Citations

Interested in seeing published research using our LNA?

Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution

^{_{EMBO Rep    |     5 Nov 2019    |    DOI: https://doi.org/10.15252/embr.201847016}}

^{_{The locked nucleic acids (LNA) targeting ZIKV sfRNA were chemically synthesized and HPLC purified by Beijing SBS Genetech Co., Ltd. For preparation of ZIKV sfRNA-LNA complex sample, ZIKV sfRNA was mixed with LNA in a 1:10 molar ratio and incubated overnight at 4°C, further purified with SEC column, and then exchanged into SAXS buffer as above.}}

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory