Description

Unlock the potential of gene regulation with Antisense Oligonucleotides (ASOs). These remarkable single-stranded DNA or RNA sequences, spanning 15-25 nucleotides, precisely target and pair with complementary genes. By skillfully obstructing gene transcription or translation, ASOs pave the way for advanced gene therapy. Their unparalleled advantages, including exceptional specificity, efficiency, and low toxicity, propel groundbreaking advancements in the field.

In the realm of gene-targeted therapeutic drugs, ASOs have emerged as game-changers. However, natural ASOs encounter hurdles such as degradation, limited specificity, and unwanted side effects. To overcome these challenges, our therapeutic ASOs are meticulously engineered with specific chemical modifications. These modifications bolster stability within the body, amplify specificity, and mitigate toxicity concerns.

Impeccable quality is our commitment. Our provided ASOs strictly adhere to rigorous QC testing standards, including comprehensive HPLC purity analysis. This stringent approach guarantees the delivery of ASO products of the highest caliber, empowering your research endeavors.

Features

• Manufacturing Capability: Our synthesis capabilities range from µg to g scale, catering to your needs from research-grade to manufacturing-grade requirements.
• Fast Delivery: With flexible project scheduling, we ensure quick turnaround times for timely delivery.
• Strict Quality Control: Our products adhere to strict quality control measures.
• Quality Analysis: We utilize HPLC and LC-Mass analysis, offering endotoxin and bioburden detection for cellular experiments.
• Expertise and Professionalism: Our team of nucleic acid synthesis experts provides specialized technical support.
• High Customization: We offer a wide range of modification options and flexible synthesis specifications to meet your specific needs.

Experience the power of our services, combining manufacturing capabilities, fast delivery, rigorous quality control, advanced analysis techniques, expert knowledge, and high customization options. Partner with us to unlock the full potential of nucleic acid synthesis and advance your research and manufacturing endeavors.

Service Details

• Yield: Research-grade (ug-mg), Manufacturing-grade (g)
• Purification Method: HPLC
• Modification Types: PTO, 2′-F, 2′-OME, 2′-MOE, LNA, Cholesterol, GalNAc, etc.

Deliverables

• Powder delivery, packaging according to customer requirements
• Certificate of Analysis (COA)

Related: Probes for Quantitative, Real-time PCR, Molecular Beacons, Oligonucleotide Conjugates

Learn More

Major antisense oligonucleotide (ASO) drugs along with their CAS numbers and modification types:

1. Inotersen (Trade name: Tegsedi)

   • CAS number: 1492984-65-2

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl (MOE) modifications, enhancing stability and reducing nuclease degradation.

2. Eplontersen

   • CAS number: 1637600-16-8

   • Modifications: Same nucleotide sequence as Inotersen, integrated with GalNAc delivery system (N-Acetylgalactosamine modification) to improve efficacy and reduce dosage frequency.

3. Mipomersen (Trade name: Kynamro)

   • CAS number: 629167-92-6

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications to increase RNA-binding capacity and stability.

4. Volanesorsen (Trade name: Waylivra)

   • CAS number: 915430-78-3

   • Modifications: Second-generation 2'-O-Methoxyethyl (2'-MOE) modifications for improved solubility and RNA targeting specificity.

5. Givosiran (Trade name: Givlaari)

   • CAS number: 1639325-43-1

   • Modifications: Double-stranded small interfering RNA (siRNA) drug with phosphate backbone modifications to enhance stability and reduce immunogenicity.

6. Nusinersen (Trade name: Spinraza)

   • CAS number: 1258984-36-9

   • Modifications: 2'-O-Methoxyethyl (MOE) modifications and phosphorothioate backbone, optimizing RNA splicing and improving stability.

7. Fomivirsen (Trade name: Vitravene)

   • CAS number: 155051-26-6

   • Modifications: Phosphorothioate backbone for enhanced stability and reduced degradation.

8. Golodirsen (Trade name: Vyondys 53)

   • CAS number: 1922968-73-7

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications for exon skipping.

9. Eteplirsen (Trade name: Exondys 51)

   • CAS number: 1173755-55-9

   • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications for exon skipping.

10. Tofersen (Trade name: Qalsody)

    • CAS number: 1633725-16-7

    • Modifications: Phosphorothioate backbone and 2'-O-Methoxyethyl modifications to lower SOD1 protein levels.

SBS Genetech is recognized as one of the global major leading industry players in Oligonucleotide Synthesis by third-party market researchers. For more details, please visit Oligonucleotide Synthesis Services Market landscape, Top Competitor Analysis, Revenue, Sales With Forecast Data from 2022 to 2028.