Peptides, with their diverse array of applications in pharmaceuticals, biotechnology, and beyond, have long been the focus of intense research and development. The synthesis of peptides, however, has historically presented challenges, particularly when it comes to longer sequences spanning 100 to 200 residues. Traditional methods of peptide synthesis often struggle to accommodate these lengthy sequences, leading researchers to rely on E. coli expression systems as a workaround. While effective, this approach comes with its own set of drawbacks, including time-consuming processes and potential inaccuracies.

Conventional wisdom has dictated that chemical synthesis methods are ill-suited for the production of long peptides. The complexity of assembling hundreds of amino acids in a specific sequence, coupled with the propensity for errors and impurities to accumulate, has made chemical synthesis a less appealing option for researchers seeking long peptides. As a result, the field has largely turned to biological expression systems, such as E. coli, as the preferred method for obtaining long peptides.

However, at SBS Genetech, we're challenging this conventional wisdom head-on. With a steadfast commitment to innovation and a deep understanding of peptide chemistry, we've developed a revolutionary approach to long peptide synthesis that is faster, more cost-effective, and unfailingly precise.

Our journey begins with a thorough understanding of the limitations inherent in traditional peptide synthesis methods. While biological expression systems offer certain advantages, including the ability to produce complex peptides, they also come with significant drawbacks. These drawbacks include the time and resources required for culturing and expression, the potential for misfolding or aggregation of the peptide, and the risk of contamination with host cell proteins.

In contrast, chemical synthesis methods offer a streamlined alternative that circumvents many of these challenges. By leveraging state-of-the-art technologies and methodologies, we've perfected the art of synthesizing long peptides with unparalleled efficiency and accuracy. Our approach allows us to rapidly assemble complex peptide sequences, eliminating the need for laborious culturing and expression steps.

One of the key advantages of our approach is the ability to control every aspect of the synthesis process, from the selection of amino acids to the optimization of coupling reactions. This level of control ensures that each peptide is synthesized with the utmost precision, resulting in a final product that is free from errors and impurities.

But our innovation doesn't stop there. At SBS Genetech, we're constantly pushing the boundaries of peptide synthesis, exploring new techniques and methodologies to further enhance our capabilities. Our long peptide synthesis technology, for example, allows us to incorporate non-genetically encoded structures, such as D-amino acids, into peptide sequences, opening up a world of possibilities for peptide design and functionality.

Moreover, our expertise in incorporating artificial amino acids with isosteric side chains enables precise investigations into the functional significance of specific residues within the peptide sequence. This level of customization and control is unparalleled in the field of peptide synthesis, offering researchers unprecedented flexibility in their experimental designs.

In conclusion, SBS Genetech is at the forefront of revolutionizing Custom Peptide Synthesis. Our innovative approach to long peptide synthesis represents a paradigm shift in the field, offering researchers a faster, more cost-effective, and more precise alternative to traditional methods. With our cutting-edge technologies and unwavering commitment to excellence, we're empowering researchers to unlock new frontiers in biology, medicine, and beyond. Contact us today and embark on your next peptide synthesis journey with SBS Genetech, your trusted ally in advancing scientific exploration.

Featured Publications

• Yang M, Chen J, Li X, Huang J, Wang Q, Wang S, Wei S, Qin Q. The transcription factor NFYC positively regulates expression of MHCIa in the red-spotted grouper (Epinephelus akaara). Dev Comp Immunol. 2021 Sep 29;127:104272.
• Wu X, Li Y, Xu H, Chen Y, Mao H, Ma Q, Du Q, Gao P, Xia F. Exponential Increase in an Ionic Signal: A Dominant Role of the Space Charge Effect on the Outer Surface of Nanochannels. Anal Chem. 2021 Sep 28.
• Yaghoubi P, Bandehpour M, Mohebali M, Akhoundi B, Kazemi B. Designing and Evaluation of a Recombinant Multiepitope Protein by Using ELISA for Diagnosis of Leishmania infantum Infected in Dogs. Iran J Parasitol. 2021 Jul-Sep;16(3):377-385.
• Xiao PP, Wan QQ, Liao T, Tu JY, Zhang GJ, Sun ZY. Peptide Nucleic Acid-Functionalized Nanochannel Biosensor for the Highly Sensitive Detection of Tumor Exosomal MicroRNA. Anal Chem. 2021 Aug 10;93(31):10966-10973.
• Georgieva M, Heinonen T, Vitale A, Hargraves S, Causevic S, Pillonel T, Eberl L, Widmann C, Jacquier N. Bacterial surface properties influence the activity of the TAT-RasGAP_317-326 antimicrobial peptide. iScience. 2021 Jul 30;24(8):102923.
• Xu R, Li Y, Sui Z, Lan T, Song W, Zhang M, Zhang Y, Xing J. A C-terminal encoded peptide, ZmCEP1, is essential for kernel development in maize. J Exp Bot. 2021 Jul 28;72(15):5390-5406. doi: 10.1093/jxb/erab224. PMID: 34104938.
• Gu H, Ma K, Zhao W, Qiu L, Xu W. A general purpose MALDI matrix for the analyses of small organic, peptide and protein molecules. Analyst. 2021 Jun 14;146(12):4080-4086.
• Dong L, Tan CW, Feng PJ, Liu FB, Liu DX, Zhou JJ, Chen Y, Yang XX, Zhu YH, Zhu ZQ. Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages. Mol Immunol. 2021 Jul;135:294-303.
• Heinonen T, Hargraves S, Georgieva M, Widmann C, Jacquier N. The antimicrobial peptide TAT-RasGAP_317-326 inhibits the formation and expansion of bacterial biofilms in vitro. J Glob Antimicrob Resist. 2021 Jun;25:227-231.
• Wang Y, Xie X, Liu H, Liu H, Jiang H. LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure. Mediators Inflamm. 2021 May 28;2021:2327721.
• Gong W, Liang Y, Mi J, Jia Z, Xue Y, Wang J, Wang L, Zhou Y, Sun S, Wu X. Peptides-Based Vaccine MP3RT Induced Protective Immunity Against Mycobacterium Tuberculosis Infection in a Humanized Mouse Model. Front Immunol. 2021 Apr 26;12:666290.